How to avoid unhealthy advanced glycation end products.

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It’s no secret that the modern, Western diet can be detrimental to your health. It contains way too many processed foods and a lot of bad fats and sugars. 

It’s also very calorie-dense all while being poor in nutrients. These are all facts you probably know. But there’s also something else to watch out for— something that you’ve most likely never heard of before. I’m talking about advanced glycation end products. What?

That’s right, these little compounds form in heat-processed foods and are highly inflammatory. But the good news is that you can avoid them.


What are advanced glycation end products?

Advanced glycation end products (AGEs) are created when proteins or fats combine with sugars in the blood. They can also form in certain foods, especially those that have been exposed to high temperatures. This impacts normal cell function, leading to quicker damage. While AGEs accumulate naturally with aging, your body is generally able to eliminate them. However, if you consume too many, it could have trouble keeping up. 1


Where do you find them?

Advanced glycation end products are naturally present in uncooked animal foods, such as red meat, certain cheeses, butter, or fried eggs. You can also find them in fatty foods such as mayonnaise, oils, and nuts. Processed sugary items, such as candy and cakes, also contain AGEs. 

Carbohydrates, and more specifically foods such as grains, legumes, bread, and fruit contain the least amount of AGEs. Vegetables and milk are also among the lowest in AGES. 2 This amount is also related to cooking temperature and cooking time

Broiling (exposing the food to direct radiant heat, like grilling on the barbecue) and frying foods give the highest AGE levels. Baking, roasting, and toasting also raise your intake of AGEs. 3 


Why are advanced glycation end products bad?

An excess of advanced glycation end products can enhance oxidative stress and inflammation4

These compounds have also been linked to aging. They play a role in the development of diseases such as diabetes, Alzheimer’s, or heart disease. Studies in mice have shown that dietary AGEs are associated with atherosclerosis and kidney disease

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    Conversely, restricting these compounds prevents these diseases, as well as diabetes. Limiting dietary AGEs also improves wound healing as well as insulin sensitivity, and lengthens lifespan

    In humans, AGE restriction reduces markers of inflammation and oxidative stress. Chronic inflammation is a general cause for many diseases, and can damage your whole body. In short, avoiding food containing AGEs could help delay chronic diseases and aging5

    bacon contains advanced glycation end products


    How can you avoid them?

    Limiting foods high in AGEs would be an excellent start. While there are currently no clear guidelines on what would be a safe advanced glycation end product intake, a high-AGE diet is often seen as anything over 15,000 AGE kilounits (kU) daily, 15000 kU being the average consumption in New-York. Therefore, anything under that is low. Here are some examples of different foods with high AGE levels for a standard serving size. 6


    Foods with high AGE levels:

    • 13 grams of fried bacon: 11,905 kU
    • 90 grams of
      • broiled frankfurter beef: 10,143 kU
      • McDonald’s chicken nuggets: 7,764 kU
      • chicken breast with skin: 7,420 kU
    • 100 grams of thin-crust pizza: 6,825 kU
    • 90 grams of
      • broiled beefsteak: 6,731 kU
      • sautéed tofu: 5,289 kU
    • 30 grams of
      • soft cream cheese: 3,265 kU
      • roasted cashews: 2,942 kU
      • peanut butter: 2,255 kU
      • roasted almonds: 1,995 kU
    • 1 large fried egg: 1,237 kU

    Therefore, limit the above foods and more generally meat, animal products, and processed foods to avoid ingesting too many AGEs. Prefer foods such as grains, legumes, bread, pasta, vegetables, and fruit.


    In addition, an efficient way to reduce your intake of foods high in AGEs is to change your cooking methods. Cooking with moist heat, using shorter cooking times, and opting for lower temperatures help keep AGE formating low. For example, stewing, boiling, and steaming are better cooking options than grilling, broiling, and frying. 

    barbecue causes advanced glycation end products

    You can also marinate meat and other foods high in AGEs in acidic solutions, such as lemon juice and vinegar. The acidity reduces the number of AGEs in the foods.

    Furthermore, some elements such as antioxidants and plant phenols can reduce AGE formation and their negative health effects. 7 
    By eating plenty of fruit and vegetables, you can limit the effects of AGEs. 

    Finally, exercise is also beneficial for reducing AGE levels. A study showed that women who exercised more (performed a higher number of daily steps) had decreased AGE levels compared to those who moved less. 


    Advanced glycation end products in conclusion

    Advanced glycation end products are compounds that form naturally with aging and are present in certain foods. While your body can generally eliminate them, modern diets contain abnormally high AGE levels. AGEs are associated with many health issues, such as diabetes, kidney diseases, or Alzheimer’s. 

    Thankfully, you can easily reduce your AGE levels. Choose whole foods such as grains, legumes, fruits, and vegetables rather than processed foods and meat. Change up your cooking methods for healthier ones like boiling and steaming with lower temperatures, less cooking time, and more humidity. Finally, make sure to stay active!


    Had you heard about advanced glycation end products before?

    If you’re interested in nutrition, its impact on our health, and the science behind it, you should definitely read How Not to Die. In this book, Doctor Michael Greger, founder of Nutrition Facts, examines the top causes of death in America and explains how your diet can prevent— and in some cases even reverse— them. His advice is all backed by science and he writes in a very clear and entertaining way. This book isn’t a list of what you already know. It will teach you the keys to living a long healthy life, in a simple and practical way, and without spending fortunes on supplements and pills!

    PLUS if you want to take it a step further, you can check out the How Not to Die Cookbook to implement the advice easily!

    Lucie Villeneuve nutritionist


    I'm Lucie, the nutritionist behind Edukale! If you'd like to learn more about me, click HERE !


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