How the food matrix effect actually impacts your nutrition.

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Ever heard of the food matrix effect?

Probably not, but the concept might sound familiar.

Do you know why supplements don’t work as well as eating the vitamins from the whole food?

Or why the fructose in fruit is healthy while the one in soda is not

All of the different macro and micronutrients of a food interact and come together to make its matrix. Each food has its unique matrix, and therefore its own specific effect on your body

Hence, a food product is more than the sum of its nutrients.

So, what does this mean?

The food matrix effect impacts your health and nutrition



What is the food matrix?

A food is made up of different components: nutrients, vitamins, minerals, water, fiber, polyphenols…the list goes on. They all interact with each other physically and chemically, giving specific properties to the food. 

These interactions determine the food’s health benefits and physiological effects

This complex and unique structure is the food matrix. Matrices take on different forms in different foods: fibrous, liquid, crumbly, gel-like…

If you isolate each individual compound of the food, they will behave differently than inside the whole food. Basically, a food is more than the sum of its nutrients.


How does the food matrix modulate a food’s effect?

A food’s matrix affects the availability of its nutrients and calories [1]. To start with, it plays a role in our satiety: eating an orange will be more filling than drinking its juice. 

It also influences the digestion of a food product and the absorption of its nutrients. Some foods may contain nutrients that your body won’t have access to. Others may give you more energy than what is written on the label. 

While these nutritional labels are an important tool, you have to keep in mind that they aren’t exhaustive. Two food products can have similar labeling but different effects on your body. 

orange and orange juice

A food is more than its label

The calories you see on a food label aren’t always what you get

Indeed, a small study showed that the actual energy content people got from almonds was different than the one written on the label. By controlling what the individuals ate and rejected (feces and urine), it was shown that they were getting “only”  129 calories per serving of almonds, while the expected energy content was 168-170 calories. 

The systems used to calculate a food’s energy content aren’t always extremely accurate[2] Again, a food is more than the sum of everything listed on its label.

This is one of the reasons why I’m not a big fan of calorie counting for weight loss (though I fully acknowledge its importance for some). You can’t be entirely sure of the energy content you are getting.

So does this mean that you shouldn’t pay attention to a nutritional label?

No, of course not: it still gives very valuable information. But don’t stop there. A food could be super processed and still have good ingredients on the label. You need to take everything into account.

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    Whole foods vs processed foods

    When you eat whole foods, your body takes time to break down the food’s structure and release the nutrients. They are delivered slowly to your body and sometimes, to a lesser degree. 

    Eating a whole apple for instance, takes some significant biting and chewing before you can get to the end of it. Very different from the 3 seconds it takes to drink a glass of apple juice. 

    The fiber contained in the apple will also slow down the release of sugar and the digestion process. In addition, fiber takes up room in your stomach. 

    For all of these reasons, eating an apple will make you fuller for longer (and I’m not even talking about the diminished vitamin content in the juice.) When you eat apple sauce, things are somewhere in the middle.

    In general, the more processed the food, the more messed up the matrix. Cooking, mixing, juicing, and even cutting a food all alter its matrix as well. This can be both good and bad, however. 

    For example, soaking and cooking beans before eating them alters their matrix, but also gets rid of antinutrients and makes the healthy nutrients accessible. On the other hand, eating refined carbs instead of whole grains provide you with accessible carbs that will get absorbed in no time.

    Foods vs supplements

    foods versus supplements

    The food matrix effect is also applied to supplements. 

    A whole food contains nutrients in a complex, natural form, while a pill concentrates nutrients into a processed form. In theory, a multivitamin would meet your vitamin needs. But in reality, these vitamins aren’t absorbed as efficiently and don’t always have the desired effect. 

    For instance, beta-carotene, an antioxidant found in carrots, sweet potatoes, red pepper, or apricots, has many great health benefits. However, beta-carotene in supplement form may actually have adverse effects. Indeed, a number of studies found that they could increase the risk of lung cancer among smokers, for instance.

    This doesn’t mean that you should ban supplements from your life: they can be helpful in some cases. However, it’s important to be aware of their potential effects and to discuss this with a doctor. In addition, supplementing shouldn’t be your main health strategy: focus on eating whole, healthy foods first.

    So what should you do with this information?

    You may be wondering how to implement this food matrix knowledge in your daily life

    First of all, simply being aware of it is already a big step. Know that the food you eat is more than the sum of its nutrients. Realize that labels, while very useful, don’t give you the full picture

    It’s important to focus on eating whole, unrefined foods instead of processed foods as much as possible. This will maximize the benefits of the food matrix.

    The more processing a food has been through before you process it yourself, the more limited its benefits will be

    Finally, try to get all of your nutrients through food rather than from supplements. This is the best way to get the benefits without the risks. 

    Of course, supplements can be helpful and even crucial in some cases, such as B12 for vegans for instance. But make sure to discuss supplementing with your doctor to find out the best option for you.

    fruit and vegetables whole foods

    The food matrix in conclusion

    A food has a matrix made up of different components that all interact together

    The food matrix effect means that different foods have different benefits and physiological effects, even if they seem similar. The more processed the food, the more altered the matrix, and the fewer benefits you will reap. 

    Focus on choosing whole, unprocessed foods instead of refined foods, and use supplements only if necessary.


    If you’re interested in nutrition, its impact on our health, and the science behind it, you should definitely read How Not to Die. In this book, Doctor Michael Greger, founder of Nutrition Facts, examines the top causes of death in America and explains how your diet can prevent— and in some cases even reverse— them. His advice is all backed by science and he writes in a very clear and entertaining way. This book isn’t a list of what you already know. It will teach you the keys to living a long healthy life, in a simple and practical way, and without spending fortunes on supplements and pills!

    PLUS if you want to take it a step further, you can check out the How Not to Die Cookbook to implement the advice easily!

    Lucie Villeneuve nutritionist


    I'm Lucie, the nutritionist behind Edukale! If you'd like to learn more about me, click HERE !


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